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To assess circumpapillary retinal arteries and veins thickness (cRAT and cRVT) at optic disc (OD) border and correlate them with circumpapillary retinal nerve fiber layer (cRNFL)
Author(s) -
PEREIRA I,
WEBER S,
HOLZER S,
RESCH H,
KISS B,
FISCHER G,
VASS C
Publication year - 2012
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2012.f013.x
Subject(s) - nerve fiber layer , retinal , ophthalmology , medicine
Purpose To assess circumpapillary retinal arteries and veins thickness (cRAT and cRVT) at optic disc (OD) border and correlate them with circumpapillary Retinal Nerve Fiber Layer (cRNFL). Methods 123 healthy subjects underwent complete ophthalmologic examination including Cirrus®HD‐OCT and GDx‐ECC® (both Carl Zeiss Meditec Inc.). We used SLO images of HD‐OCT and MATLAB® (Version R2009b, The Mathworks Inc.) to manually identify the OD contour and measure cRAT and cRVT at OD border. cRAT and cRVT data were convolved with a Gaussian window to generate a 64‐sector profile. Results 123 and 118 subjects showed significant intrasubject correlations between the cRNFL thickness profiles of the GDx‐ECC and cRVT and cRAT profiles, with Rmean 0.68 (0.96 – 0.03) and Rmean 0.65 (0.92 – 0.02). 26 and 24 of 64 plots showed significant intersubject correlation between cRNFL and cRVT and cRAT profiles (Rmax 0.35 and 0.29). For all vessels together intrasubject Rmean was 0.74 (0.40 – 0.96). Intersubject correlation was significant in 33/64 plots (Rmax 0.37). Conclusion The individual cRVT and cRAT profiles contain approximately 46% of the individual RNFL profile information. Up to 12% of the intersubject variability of cRNFL might be explained by variations of cRVT or cRAT profiles. Analyzing all vessels together performed even slightly better.