Premium
24‐hour intraocular pressure of healthy humans in supine position: rhythm and reproducibility
Author(s) -
MOTTET B,
CHIQUET C,
APTEL F,
NOEL C,
ROMANET JP
Publication year - 2012
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2012.f003.x
Subject(s) - supine position , medicine , intraocular pressure , rhythm , reproducibility , circadian rhythm , ophthalmology , anesthesia , cardiology , mathematics , statistics
Purpose To evaluate the reproducibility over time of 24H intraocular pressure (IOP) rhythm in healthy humans in supine position. Methods In a sleep laboratory, six healthy young Caucasian male subjects were included in each six weekly 24H sessions of hourly IOP measurements in a control supine position using the pneumatonometer Digilab Modular One. IOP 24H rhythm was modelled using a nonlinear least squares dual harmonic regression analysis. The intra‐ and inter‐subject variability of acrophase, bathyphase, amplitude and IOP values were evaluated. Results A significant nyctohemeral IOP rhythm was noted in 30/36 (83%) sessions. Nocturnal IOP was significantly higher than diurnal IOP (20.1 ± 0.2 vs. 18.8 ± 0.1 mmHg). Reproducible distribution over 24H of intra‐subject acrophase and bathyphase was found respectively in 3/6 (50%) and 4/6 (67%) subjects. Intra‐subject means of amplitude were not statistically different between subjects. IOP values at 2:00, 3:00, 4:00, 10:00, 11:00 AM and 2:00 PM and IOP mesor had fair to good agreement between sessions. Conclusion Most healthy subjects exhibited a nyctohemeral rhythm of IOP with fair reproducible characteristics in supine position. Amplitude is the best reproducible parameter. This result strongly suggests that chronobiological lower IOP therapies could be powerfully studied using paired intra‐subject 24H nyctohemeral rhythm data comparison, during repeated sessions overtime before and after treatment.