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Retinal vascular caliber is associated with renal function in normotensive and never‐treated hypertensive subjects
Author(s) -
DAIEN V,
KAWASAKI R,
VILLAIN M,
FESLER P
Publication year - 2012
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2012.4743.x
Subject(s) - caliber , medicine , renal function , cardiology , ophthalmology , retinal , materials science , metallurgy
Purpose The aim of this study was to assess the relation between retinal vascular caliber and renal function in normotensive (systolic/diastolic blood pressure <140/90 mmHg) and never‐treated uncomplicated hypertensive subjects. Methods Eighty subjects (51 normotensive and 29 hypertensive , mean age 47 yrs and 51% female) with serum creatinine < 1.2 mg/dL and without diabetes were recruited. Retinal vascular calibers were measured from fundus photographs and expressed as central retinal artery and venular equivalent (CRAE and CRVE, respectively). Renal function was assessed by measurement of glomerular filtration rate (GFR, urinary clearance of 99mTc‐DTPA) and urinary albumin/creatinine ratio (UACR). Results Mean GFR was 117 ml/min/1.73m². The adjusted mean CRAE was smaller in the hypertensive group as compared to the normotensive group (mean±standard error: 135±24µm vs. 142±18µm; P=0.03); whereas adjusted mean CRVE was similar. In all participants, CRAE and CRVE were positively correlated to GFR (r²=0.09, P=0.005 and r²=0.09, P=0.006, respectively). In addition, CRAE was negatively correlated to UACR (r²=0.12, P=0.02) and no significant relationship between CRVE and UACR was found (r²=0.01, P=0.31). The observed relations between retinal vascular calibers (CRAE and CRVE) and renal function parameters (GFR and UACR) remained significant after adjusting for age, gender, mean blood pressure, smoking, glycemia, body mass index and lipid profile. Conclusion In normotensive and never‐treated hypertensive subjects with normal renal function, the decrease in retinal arteriolar and venular calibers was associated with reduced kidney function, suggesting common determinants of these preclinical target organ damages.