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Indications for intraarterial chemotherapy in patients with advanced retinoblastoma
Author(s) -
SAAKYAN S,
JARWAH A,
YAKOVLEV S,
KOBYAKOV G
Publication year - 2012
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2012.4662.x
Subject(s) - retinoblastoma , chemotherapy , medicine , surgery , biochemistry , chemistry , gene
Purpose Despite the use of new methods of treatment for retinoblastoma their efficacy remains debatable and depends on different factors. Our aim was to determine the indications and efficacy of intraarterial chemotherapy in patients with different growth pattern in advanced retinoblastoma. Methods For the period of last year 20 children (26 eyes) were treated for advanced and resistant retinoblastoma . 12 had monocular and 8 binocular RB. Age from 12 months to 6 years. 16 out of 20 children have had systemic chemotherapy. 13 patients have had exophytic growth and 7 – endophytic. All patients were treated with intraarterial chemotherapy with melfolan 7.5 mg (1‐3 injections). Results We were able to preserve 21 eyes out of 26 eyes. The retrospective analysis has showed that the enucleated eyes had endophytic growth with massive seeding of tumour into the vitreous body. The best effect after chemotherapy has been observed in untreated patients with exophytic growth and juxtopapillary localization. Conclusion Our experience shows that intraarterial chemotherapy in patients with endophytic growth of retinoblastoma has very low efficacy. The choice of method of treatment depends on tumour growth pattern, localization and duration of earlier done systemic chemotherapy.