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Correlation between function and structure of retinal nerve fiber layer in Parkinson disease
Author(s) -
SATUE M,
BAMBO M,
GARCIAMARTIN E,
FERRANDEZ B,
GILARRIBAS LM,
ARA M
Publication year - 2012
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2012.4474.x
Subject(s) - nerve fiber layer , ophthalmology , medicine , retinal , correlation , optical coherence tomography , absolute deviation , nerve fiber , visual acuity , anatomy , mathematics , statistics , geometry
Purpose To determine the capacity of the axonal application for Optical Coherence Tomography (OCT) to detect axonal loss in the retinal nerve fiber layer (RNFL) in Parkinson’s disease (PD) and to evaluate the structure/function relationship between OCT measurements and visual function tests. Methods One hundred patients and 100 controls were included in the study and underwent a complete neuro‐ophthalmologic examination consisting in best corrected visual acuity (BCVA), color vision test with Ishihara’s pseudoisochromatic charts, automatic perimetry with Strategy SITA standard 30.2 of Humphrey and Spectralis OCT using the new axonal application. Mean and standard deviation of all parameters were calculated and correlation between RNFL, BCVA, Ishihara test’s score and the mean and mean standard deviation of the automatic perimetry. Results Significant differences between controls and patients were found in inferior and temporoinferior RNFL thicknesses (133.18 in controls vs 125.03 µm in PD, p=0.006; 149.53 vs 141.32 µm, p=0.020 respectively) and sector number 8 in papillomacular bundle (306.13 vs 271.19 µm, p= 0.006). Significant differences were also observed in automatic perimetry and Ishihara’s score (p<0.001). The RNFL thickness of the papillomacular bundle showed strong correlation (correlation index >0.700) with perimetry values and mild association with Ishihara’s score. Conclusion RNFL loss is detectable by the axonal application of Spectralis OCT in Parkinson disease. Functional parameters obtained by automatic perimetry present strong association with papillomacular bundle measurements.