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Quantification of axonal loss in pseudotumor cerebri syndrome using macular thickness measurements with frequency domain‐OCT
Author(s) -
MONTEIRO M,
AFONSO C
Publication year - 2012
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2012.4473.x
Subject(s) - papilledema , pseudotumor cerebri , medicine , ophthalmology , optical coherence tomography , surgery , intracranial pressure
Purpose To evaluate the ability of fourier domain‐optical coherence tomography (FD‐OCT)‐measured macular thickness parameters to differentiate between eyes with chronic papilledema from pseudotumor cerebri (PTC) and healthy eyes and its relationship with visual field (VF) loss on standard automated perimetry (SAP). Methods Fifty‐five eyes from 30 patients with PTC syndrome and 70 eyes from 35 normal controls underwent FD‐OCT (3D OCT‐1000, Topcon) scanning and ophthalmic evaluation including SAP using Humphrey perimetry. All patients had been submitted to previous treatment with clinically resolved papilledema and stable VF for at least 6 months. Macular and peripapillary RNFL thickness measurements were determined. Comparisons were made using Generalized Estimated Equations. Correlations between OCT and VF measurements were also verified. Results All macular and most RNFL thickness measurements were significantly reduced in eyes with resolved papilledema from PTC syndrome compared to normal controls. Although both OCT‐measured macular and RNFL thickness measurements correlated with visual loss on SAP, correlation coefficients were greater for former. Conclusion Eyes with chronic papilledema show significant macular thinning which is correlated with the severity of VF loss. Macular thickness measurements could potentially estimate the amount of ganglion cell loss during follow‐up of patients with pseudotumor cerebri syndrome.