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Local recurrence after uveal melanoma protontherapy: prognostic consequences
Author(s) -
CAUJOLLE JP,
PAOLI V,
CHAMOREY E,
MASCHI C,
HANNOUNLEVI JM
Publication year - 2012
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2012.4461.x
Subject(s) - medicine , survival rate , log rank test , survival analysis , proportional hazards model , melanoma , retrospective cohort study , population , univariate analysis , surgery , multivariate analysis , environmental health , cancer research
Purpose To study the prognosis of the different types of uveal melanoma recurrences treated by proton beam therapy Methods This retrospective study analyzed 61 cases of uveal melanoma local recurrence on a total of 1102 patients treated with protontherapy between June 1991 and December 2010. Survival rates have been determined by using Kaplan‐Meier curves. Prognostic factors have been evaluated by using Log‐rank test or Cox model. Results Our local recurrence rate was 5.5%. These recurrences were divided into: 25 patients with marginal recurrences, 18 global recurrences, 12 far recurrences and 6 extra‐scleral extensions. 4 factors have been identified as statistically significant risk factor of local recurrence in univariate analysis: large tumoral diameter, weak tumoral volume, weak ratio of tumoral volume over eyeball volume and safety margin inferior to 1 mm. In the local recurrence free population, the overall survival rate was 59.8% at 15 years and the specific survival rate was 80.9% at 15 years. In the local recurrence population, the overall survival rate was 34.5% at 15 years and the specific survival rate was 55% at 15 years. Kaplan‐Meier survival curves have shown a better prognosis for marginal recurrences compared to the other recurrences. Conclusion Survival rate of marginal recurrences is highly superior to the other recurrences. The type of recurrence is an important clinical prognostic value to know.