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Parapapillary atrophy: histological gamma zone and delta zone
Author(s) -
JONAS JB,
JONAS S,
JONAS R,
HOLBACH L,
DAI Y,
SUN X,
PANDAJONAS S
Publication year - 2012
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2012.4452.x
Subject(s) - glaucoma , ophthalmology , optic nerve , anatomy , bruch's membrane , intraocular pressure , medicine , retinal , optic cup (embryology) , retinal pigment epithelium , chemistry , biochemistry , gene , eye development , phenotype
Purpose To examine histomorphometrically the parapapillary region in human eyes Methods The histomorphometric study included 65 human globes (axial length:21‐37mm). On anterior‐posterior histological sections, we measured the distance Bruch´s membrane end (BME)‐optic nerve margin (“Gamma zone”), BME‐retinal pigment epithelium (RPE) (“Beta zone”), BME‐beginning of non‐occluded choriocapillaris, and BME‐beginning of photoreceptor layer. “Delta zone” was defined as part of gamma zone in which blood vessels of at least 50µm diameter were not present over a length of >300µm. Results Beta zone (mean length:0.34±0.52mm) was significantly (P=0.046) larger in the glaucoma group than in the non‐glaucomatous group. It was not significantly (P=0.28) associated with axial length. Beta zone was significantly (P=0.03) larger than the region with occluded choriocapillaris. Gamma zone (mean length:0.63±1.15mm) was associated with axial length (P<0.001;r2=0.72) with an increase starting at an axial length of 26.5mm. It was not significantly (P=0.24) associated with glaucomatous optic neuropathy. Delta zone (present only in eyes with axial length of ≥27mm) was associated with axial length (P=0.04) but not with glaucoma (P=0.18). Conclusion Parapapillary gamma zone was related with axial globe elongation and was independent of glaucoma. Beta zone (Bruch´s membrane without RPE) was correlated with glaucoma but not with globe elongation. Since the region with occluded choriocapillaris was smaller than beta zone, complete loss of RPE may have occurred before complete choriocapillaris closure. Delta zone was present only in highly axially elongated globes.