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Metabolism in glaucoma using retinal oximetry
Author(s) -
STALMANS I
Publication year - 2012
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2012.3652.x
Subject(s) - retinal , glaucoma , ophthalmology , medicine , visual field , nerve fiber layer , oxygen saturation , atrophy , saturation (graph theory) , oxygen , optic nerve , chemistry , mathematics , organic chemistry , combinatorics
Collaborative studies between the Ophthalmology departments in Leuven and Reykjavik have shown that in glaucoma patients, venous oxygen saturation increases with increasing severity of disease (i.e. with worsening visual field). Patients with considerable visual field loss show higher venous oxygen saturation than healthy individuals, while glaucoma patients with mild visual field loss have saturation similar to normal. Moreover, severe glaucomatous damage was associated with increased oxygen saturation in the retinal venules and decreased AV‐difference in retinal oxygen saturation. Finally, a positive correlation between the changes in AV difference and structural changes at the level of the optic disc and nerve fiber layer was found using HRT parameters (rim area, retinal nerve fiber layer thickness). The increase in venous saturation with increased visual field damage may be a consequence of tissue atrophy and less oxygen consumption. Longitudinal studies of glaucoma patients are needed to determine how retinal venous oxygen saturation is related to progression.