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Gene therapy approaches in corneal pathologies
Author(s) -
FUCHSLUGER T
Publication year - 2012
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2012.3631.x
Subject(s) - cornea , gene transfer , corneal transplantation , genetic enhancement , corneal diseases , transduction (biophysics) , medicine , signalling pathways , presentation (obstetrics) , gene , corneal transplant , bioinformatics , ophthalmology , biology , surgery , genetics , biochemistry
Purpose This lecture will provide an overview over past and current gene therapy approached to treat corneal pathologies. Methods The presentation will include both viral and non‐viral gene transfer strategies and will present data from the authors and other research groups. Results Depending on the carrier transduction rates of corneal cells vary. However, outcome has ben promising, also during corneal storage and after corneal transplantation. Conclusion Gene therapy to the cornea is a relatively new but promising field.