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Immune modulatory effects of gene therapy to corneal grafts
Author(s) -
FUCHSLUGER T
Publication year - 2012
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2012.2745.x
Subject(s) - immune system , corneal transplantation , transduction (biophysics) , genetic enhancement , immunology , transplantation , gene , medicine , apoptosis , gene transfer , cancer research , biology , genetics , surgery , biochemistry
Purpose To provide an overview of immune modulatory effects of gene therapeutival aproaches to corneal allografting. Methods The immune reactions caused by corneal allografting will be summarized. Gene therapeutical approaches will be presented, e.g. after transduction of epithelial cells with anti‐apoptotic p35 in the mouse model. Results Transduction with p35 leads to a reduced immune response. Further insight into the immune modulatory effects will be presented. Conclusion Anti‐apoptotic gene transfer leads to a reduced immune response in corneal transplantation. This might offer a way to increase success rate after transplantation of a corneal allograft.