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Evaluation of retrobulbar hemodynamics and aqueous humor levels of Endothelin‐1 in exfoliation syndrome, exfoliative glaucoma and primary open‐angle glaucoma
Author(s) -
NASR MB,
KOUKOULA SC,
TRANOS PG,
LABIRIS G,
KOZOBOLIS VP
Publication year - 2012
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2012.2654.x
Subject(s) - medicine , glaucoma , ophthalmology , open angle glaucoma , aqueous humour , ophthalmic artery , central retinal artery , hemodynamics , endothelin 1 , retinal , aqueous humor , blood flow , receptor
Purpose To compare mean Endothelin‐1 (ET‐1) concentration in aqueous humor and retrobulbar hemodynamics in patients with exfoliation syndrome (XFS), exfoliative glaucoma (XFG), primary open‐angle glaucoma (POAG), and normal controls, and to evaluate the role of these index in the management of glaucoma. Methods Aqueous Humour samples were collected from 20 subjects with POAG, 18 with XFG, 20 with XFS and 19 with senile cataract (CONTROL). Pre‐surgery Color Doppler Imaging (CDI) in Ophthalmic Artery (OA), Posterior Ciliary Arteries (PCA) and Central Retinal Artery (CRA) were performed. Samples were frozen at ‐70oC and were analyzed with ELISA method. Results ET‐1 level in aqueous samples of XFS, POAG, and XFG groups were statistically higher than that in CONTROL group (p1=0,008, p2=0,005, p3=0,020). However, there was no significant difference between aqueous ET‐1 levels of the three glaucoma groups (p< 0,900). Mean EDV of Ophthalmic Artery in subjects with XFG was significantly lower (p<0.05) than the other groups (XFS, POAG, Control). The mean PSV of the Ophthalmic Artery, yet, it was not statistically different between subjects with XFG, POAG and XFS, it was significantly lower (p<0.05) when comparing XFG and control groups. Resistivity index (RI) of OA in subjects with XFG was significantly higher compared with POAG and XFS patients (p<0.05). Conclusion This study confirms a lower hemodynamics in patients with XFG, a statistically higher levels of ET‐1 in glaucoma subjects, and no significant difference between levels of ET‐1 in glaucoma groups, which may in the future, indicate a useful parameter as a result of glaucoma damage and not as cause