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Diabetic retinopathy in Greek Caucasian type 2 diabetic patients, relationship with polymorphism in the plasminogen activator inhibitor 1 and 2 genes
Author(s) -
SOKOLAKIS TH,
TSIRONI E,
DARDIOTIS E,
CHATZOULIS E,
ZINZARAS E
Publication year - 2012
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2012.2467.x
Subject(s) - linkage disequilibrium , medicine , type 2 diabetes , diabetic retinopathy , retinopathy , gastroenterology , diabetes mellitus , fibrinolysis , genotype , pathogenesis , plasminogen activator , ophthalmology , haplotype , endocrinology , genetics , gene , biology
Purpose Diabetic retinopathy is a sight thratening chronic complication of diabetes and the leading cause of acquired blindness in adults.Population and family studies showed that pathogenesis of diabetic retinopathy depends upon the interaction of several environmental and genetic factors. Plasminogen activator inhibitor 1 and 2 is the major inhibitor of fibrinolysis and gene polymorphism has been related to hypofibrinolysis. Methods A case control study was carried out.Assesment of diabetic retinopathy was performed by ophthalmoscopy and fluoroangiography when indicated.The comparison of the groups of patients was performed according to the presence or absence of diabetic retinopathy.In each patient the genotype of pai‐1 and pai‐2 was determined using PCR and RFLP techniques. Results 246 controls & 352 cases observed SERPINB2 Statistical significance of the observed linkage disequilibrium: rs2070682 rs1050813 rs2227690 rs2227692 rs2227667 1.55e‐15 3.55e‐15 1.11e‐16 2.22e‐16 rs2070682 ‐ 2.22e‐16 1.78e‐15 0 rs1050813 ‐ ‐ 2.04e‐12 2.17e‐7 rs2227690 ‐ ‐ ‐ 3.02e‐8 Global result: Fisher's p value is 0.573984 Pearson's p value is 0.573939 SERPINE1 Statistical significance of the observed linkage disequilibrium: rs2070682 rs1050813 rs2227690 rs2227692 rs2227667 1.55e‐15 3.55e‐15 1.11e‐16 2.22e‐16 rs2070682 ‐ 2.22e‐16 1.78e‐15 0 rs1050813 ‐ ‐ 2.04e‐12 2.17e‐7 rs2227690 ‐ ‐ ‐ 3.02e‐8 Global result: Fisher's p value is 0.573984 Pearson's p value is 0.573939 Conclusion Based on the primary analysis derived some important relationship between gene polymorphism and diabetic retinopathy that even last the bonferroni correction.