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Choroidal thickness in glaucoma patients and glaucoma suspects measured by spectral domain optical coherence tomography
Author(s) -
FRANCOZ A,
NICOT F,
CATTANEO A,
CREUZOTGARCHER C,
AHO S,
BRON A
Publication year - 2012
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2012.2453.x
Subject(s) - ophthalmology , glaucoma , medicine , intraocular pressure , optical coherence tomography , nerve fiber layer , retinal , normal tension glaucoma , optic nerve , visual field , choroid , open angle glaucoma , retina , optics , physics
Purpose The aim of our study was to evaluate and compare retro‐foveolar choroidal thickness (RFCT) of healthy subjects, individuals with intraocular hypertension, patients with primary open‐angle glaucoma (POAG), patients with normal tension glaucoma (NTG) and patients with primary angle‐closure glaucoma (PACG) by spectral domain optical coherence tomography (SD‐OCT). Methods Sixty‐five healthy eyes, 30 eyes with intraocular hypertension, 90 eyes with POAG, 30 eyes with NTG and 20 eyes with PACG were included in this cross‐sectional study. RFCT, foveolar retinal thickness and average retinal nerve fiber layer thickness (RNFL) were measured by SD‐OCT (Spectralis HRA‐OCT, Heidelberg Engineering). Choroidal area was measured centered on the fovea, extending 2500 μm in temporal and nasal directions with Image J software. Parapapillary atrophy (PPA) was noted with optic nerve digital stereophotography. Humphrey 24‐2 visual field was also performed and spherical equivalent (SE) was measured with an automatic refractometer. Results In univariate analysis, significant correlations were observed between RFCT and age, choroidal area, PPA (p<0.001), SE, intraocular pressure, topical prostaglandin analogs (p<0.030), POAG, PACG (p<0.001) and NTG (p=0.006). In multivariate analysis, RFCT was correlated with age, choroidal area, PPA and PACG (p<0.001). Average RFCT was statistically thicker in PACG patients compared to healthy subjects (341 ± 95 μm versus 235 ± 56 μm, p<0.001). Conclusion This preliminary study showed that RFCT measured by SD‐OCT was significantly thicker in PACG compared to healthy subjects.