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IgG4‐related orbital disease: a meta‐analysis and review
Author(s) -
Andrew Nicholas,
Kearney Daniel,
Selva Dinesh
Publication year - 2013
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2012.02526.x
Subject(s) - igg4 related disease , medicine , orbit (dynamics) , pathogenesis , disease , pancreas , lymphoma , pathology , immune system , immunology , engineering , aerospace engineering
. IgG4‐related orbital disease (IgG4‐ROD) is a recently described condition that may account for a significant proportion of idiopathic lymphoplasmacytic or sclerotic orbital lesions. This study is the first meta‐analysis of published cases and reveals several differences between IgG4‐related disease affecting the orbit and that affecting the pancreas. IgG4‐ROD affects a slightly younger group of patients, affects men and women approximately equally, is commonly associated with salivary gland lesions, is associated with a relatively higher serum IgG4 and may confer an increased risk of non‐Hodgkin Lymphoma. Its pathogenesis may involve an immune response to antigen exposure in the upper aerodigestive tract.