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Evaluation of extended release brimonidine intravitreal device in normotensive rabbit eyes
Author(s) -
Deokule Sunil P.,
Baffi Judit Z.,
Guo Hong,
Nazzaro Marty,
Kaneko Hiroki
Publication year - 2012
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2012.02418.x
Subject(s) - brimonidine , photopic vision , medicine , ophthalmology , implant , retinal , erg , electroretinography , fundus (uterus) , significant difference , intraocular pressure , surgery
. Purpose: To evaluate the safety profile of a brimonidine extended release intravitreal implant, in normotensive rabbit eyes. Methods: Devices were made from hollow poly‐l‐lactic acid (PLA) tubes and contained hundred micrograms of brimonidine pamoate. Device was injected intravitreally in one eye of 12 New Zealand pigmented rabbits, whereas other eye was injected with a sham implant in masked fashion. Ocular examination was conducted at baseline and months 1, 3 and 6 including dilated fundus examination and electro‐retinogram (ERG). Four rabbits were sacrificed at each time‐point for retinal histology. ERG data were compared between groups and time‐points using anova . Results: No complications were reported from either eye of any rabbits over a 6‐month period. Photopic A wave was reduced in the control eye at 1 month compared with baseline (p < 0.01). There was no significant difference in other ERG parameters between the groups at different time‐points. Gross retinal histology was normal at all time‐points. Conclusion: Extended release intravitreal brimonidine device was found to be safe and in normotensive rabbit eyes.