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Follicular lymphoma of the ocular adnexal region in Denmark
Author(s) -
RASMUSSEN PK,
RALFKIAER E,
PRAUSE JU,
SJÖ LD,
HEEGAARD S
Publication year - 2011
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2011.4165.x
Subject(s) - follicular lymphoma , medicine , lymphoma , stage (stratigraphy) , follicular phase , radiation therapy , conjunctiva , lacrimal gland , surgery , pathology , biology , paleontology
Purpose To characterize the clinicopathological features of follicular lymphoma of the ocular adnexal region. Methods The present nation‐based series of orbital and adnexal follicular lymphoma was collected between 1980 and 2009. Histological specimens were re‐evaluated using a panel of monoclonal antibodies. Clinical files from all patients with confirmed follicular lymphoma were collected. Results A total of 24 patients with follicular lymphoma of the ocular adnexal region were identified. Fourteen of the patients were females. The patients had a median age of 63 years (range 42 to 96 years). Eighty‐eight percent of the patients had unilateral ocular adnexal region involvement, and the most frequently affected sites were: the conjunctiva (35%), the orbit (29%), and the lacrimal gland (21%). Fifteen patients (63%) presented with Stage I lymphoma. Three patients (12%) had Stage II, one patient (4%) had Stage III, and five patients (21%) presented with Stage IV lymphoma. Patients were treated with: radiotherapy (58%), chemotherapy (37%), and surgery alone (5%). Complete remission was observed in 79% of the patients. However, seven (37%) of these had a relapse, and were treated with local radiotherapy prior to setback. The 5‐year and 10‐year overall survival rate for the whole study group was 89% and 66%. Conclusion Follicular lymphoma of the ocular adnexal region is mainly prevalent in elderly patients. The conjunctiva is the most commonly affected location. The majority of patients present with Stage I/II lymphoma, and the overall prognosis is relatively good. However, relapse or disease progression is frequently seen in this patients group.