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Measurement of retinal oxygen saturation in patients with chronic obstructive pulmonary disease
Author(s) -
PALKOVITS S,
LASTA M,
SCHMIDL D,
BOLTZ A,
TOLD R,
KAYA S,
GARHOFER G,
SCHMETTERER L
Publication year - 2011
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2011.4122.x
Subject(s) - retinal , saturation (graph theory) , copd , oxygen saturation , oxygen , medicine , oxygen therapy , fundus camera , ophthalmology , cardiology , anesthesia , chemistry , ophthalmoscopy , mathematics , organic chemistry , combinatorics
Purpose In the recent years several systems for the measurement of retinal oxygen saturation became commercially available. These systems rely on spectral analysis of the light reflected and scattered at the fundus. To measure the validity of the obtained results is difficult, because no gold standard method for the measurement of retinal oxygen saturation exists. We measured oxygen saturation in patients with reduced arterial oxygen saturation due to chronic obstructive pulmonary disease (COPD) and correlated data obtained in retinal arteries with systemic oxygen saturation values. Methods Eleven patients with COPD were included in this study and two identical study days were scheduled. The patients were in need of long term oxygen therapy to reach normal values for the oxygen saturation. Retinal arterial oxygen saturation was studied using spectral analysis of fundus photos using the Retinal Vessel Analyzer (Imedos®). Systemic oxygen saturation was studied with a pulse oximeter. The measurements were repeated 20 minutes after the oxygen therapy was paused. Results On day one systemic oxygen saturation in patients with COPD was 93 ± 4% and 86 ± 6% with and without oxygen therapy, respectively. Retinal arterial oxygen saturation was 91 ± 5% and 87 ± 6%, respectively (similar findings on day two). The correlation between systemic and retinal oxygen saturation was high (Day 1: r=0.68, p=0.023; Day 2: r=0.91,b p=0.001). In addition we found a high correlation coefficient of the change in oxygen saturation values (Day 1: r=0.88, p=<0.001; Day 2: r=0.67, p=0.047). Conclusion Our data indicate that measurements of arterial retinal oxygen saturation using the Retinal Vessel Analyzer show adequate validity.