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Anti‐VEGF treatment in ocular oncology
Author(s) -
ZOGRAFOS L
Publication year - 2011
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2011.3116.x
Subject(s) - medicine , ophthalmology , secondary glaucoma , fluorescein angiography , retinal detachment , retinal , glaucoma
Purpose To present the indications of Anti‐VEGF treatment in ocular oncology. Methods Intraocular anti‐VEGF injections were used for: • The prevention or the treatment of neovascular glaucoma following irradiation treatment of intraocular tumors (uveal melanomas, choroïdal hemangiomas, choroïdal metastasis). • The control of cystoids macula edema related to the conservative management of intraocular tumors. • The treatment of secondary retinal detachment related to vascular tumors and pseudo tumors and mainly the Coat’s disease. Results A dramatic decrease of the risk of neovascular glaucoma was obtained with intravitreal anti‐vasoproliferative treatment following irradiation treatment of intraocular tumors. The presence of retinal ischemia associated to the secondary exudative retinal detachment is observed with panoramic (150°) fluorescein angiography. The anti‐vasoproliferative treatment is delivered during the period preceding the reatachment of the retina which allows a photocoagulation treatment. Anti‐vasoproliferative treatment in case of established iris neovascularisation allows a functional success (IOP less than 20mm Hg) in 84% of the cases and anatomical success (reduction of the iris neovascularisation and of diffusion of the dye in fluorescein angiography) in 75% of the cases. Impressive reduction of the secondary retinal detachment is obtained following anti‐vasoproliferatives treatment in cases of Coat’s disease allowing the photoablation of the reattached retina. Conclusion Anti‐vasoproliferative treatment in ocular oncology is a major contribution for the reduction of side effects induced by irradiation treatment and to maintain useful function in treated eyes.