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Abnormalities of optical coherence tomography and visual evoked potentials in patients with chiasmal compression syndrome
Author(s) -
WASIK M,
PILECKI W
Publication year - 2011
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2011.310.x
Subject(s) - nerve fiber layer , medicine , optical coherence tomography , ophthalmology , retinal , evoked potential , visual evoked potentials , optic nerve , audiology
Abstract Purpose To report abnormalities of retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT) and visual evoked potentials (VEP) in patients with compressive chiasmal tumors confirmed on MRI examination. Methods 22 eyes of 12 patients with parasellar tumors causing chiasmal compression syndrome were included to the study and compared to 59 eyes of 30 healthy patients. Exclusion criteria were any other ophthalmic or general condition that can affect both VEP and OCT measurements. All patients underwent MRI of the head to confirm the diagnosis, retinal nerve fiber thickness measurements with OCT and visual evoked potentials examination. Results Average RNFL thickness in patients with chiasmal compression (OD=96,06 ± 14,2µm, OS=92,4 ± 10,2µm) was significantly lower (p=0.016 and p=0.005) than in normal eyes (OD=104,7 ± 10µm, OS=104,5 ± 15µm respectively). It was noticed also reduced RNFL thickness in nasal quadrants. Visual evoked potentials showed mean P100 latency prolongation in examined patients (OD=112 ± 8,7ms and OS=108,4 ± 7,4ms), which was statistically significant (p<0.001 and p=0.001 respectively) in comparison to control group (103,1± 4,5ms and 102,5 ± 4,2ms respectively). Conclusion In patients with compressive chiasmal syndrome both RNFL thickness measurements with OCT and visual evoked potentials were significantly changed. These methods provide useful information in the diagnosis of chiasmal lesions.