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Dynamic corneal wavefront aberrations and quality of vision in patients with dry eye disease
Author(s) -
DENOYER A,
RABUT G,
BAUDOUIN C
Publication year - 2011
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2011.2176.x
Subject(s) - ophthalmology , medicine , corneal topography , corneal disease , cornea , aberrations of the eye , visual acuity
Abstract Purpose This clinical, prospective, and comparative study was conducted to evaluate the time‐course of corneal optical quality along with patient‐centered visual deterioration in dry eye. Methods Twenty patients diagnosed for dry eye and twenty controls were included. Clinical evaluation of the ocular surface included tear break‐up time (BUT) measurement, Schirmer's test, corneal and conjunctival staining scores. Dynamic corneal aberrometry was performed using KR‐1W aberrometer (Topcon, Tokyo, Japan). Patient‐centered quality of vision was evaluated according to the Ocular Surface Disease Index (OSDI). Corneal aberration (CA) dynamics were compared between both groups then analyzed regardless to other clinical data. Results Mean slope for aberration time‐course was significantly higher in dry eye patients than in controls (P=0.01). Dry eye was associated with an increase in corneal high‐order aberrations from 3 to 10 seconds after blinking (P<0.001) mainly due to rapid increase in third‐ and fourth‐order CAs. Correlation matrix revealed significant relation between CA dynamics and BUT (P<0.001), corneal staining (P<0.001), OSDI vision‐subscore (P=0.009) and OSDI overall score (P=0.02). BUT and Oxford’s score were found to correlate with CA dynamics in multiple regression analysis. Conclusion Dynamic corneal aberrometry appears as a new objective tool to better understand visual disturbances due to dry eye, and it could constitute a repeatable and reproducible method to follow the disease and improve the therapeutic management.