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T Cells and the Eye
Author(s) -
DICK A
Publication year - 2011
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2011.2141.x
Subject(s) - inflammation , t cell , cd8 , immunology , cytotoxic t cell , compartment (ship) , infiltration (hvac) , microbiology and biotechnology , uveitis , cell , biology , immune system , genetics , in vitro , oceanography , physics , geology , thermodynamics
Purpose Experimental Autoimmune uveoretinitis (EAU) is a clinico‐pathological model of human non‐infectious uveitis. This review is to illuminate the dynamics of T cell infiltration in the eye during the course of EAU, the control of T cell activation and proliferation of T cells at the target site and ultimately control of inflammation. Methods Using models of EAU we are able to accurately dissect and enumerate T component, cyokine liberation and interrogate interactions of myeloid‐T cell compartment within the local environment during autoimmune inflammation. Results During the course of EAU, the early T cell infiltrate is seen prior to clinical disease. During acute inflammation there is a mixed T cell response, predominantly CD4+ Th1 and Th17 response. In later stages, Treg cells accumulate along with minor populations of CD8+ and NK T cells. Throughout there is close interaction with myeloid‐derived cells governing response of T cell activation and proliferation and vice versa mediated in part by TNF and TSP. Conclusion The cellular interactions within the local microenvironment regulate T cell expression.