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Recent advances in optic neuritis related to multiple sclerosis
Author(s) -
Chan Jane W.
Publication year - 2012
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2011.02145.x
Subject(s) - optic neuritis , multiple sclerosis , medicine , optical coherence tomography , atrophy , optic nerve , visual acuity , ophthalmology , retinal , visual impairment , contrast (vision) , neuroscience , pathology , psychology , psychiatry , artificial intelligence , computer science
. More advanced methods of detecting and quantifying optic neuritis (ON) in multiple sclerosis have been developed in the past 15 years. This review focuses on developments in optical coherence tomography (OCT) measurement of the retinal nerve fibre layer (RNFL) and its role in monitoring axonal loss in the course of the disease. New clinical trial methods of measuring visual acuity (VA) include high‐contrast VA testing with Early Treatment Diabetic Retinopathy Study charts, low‐contrast letter acuity and contrast sensitivity testing. Multi‐focal visual evoked potentials have been used to detect early, subtle visual impairment in ON and early recovery of visual function. New technical developments in OCT may help advance our knowledge in studying the relationship between optic nerve/retinal atrophy and brain atrophy in clinically isolated syndrome (CIS), relapsing remitting multiple sclerosis, secondary progressive multiple sclerosis and primary progressive multiple sclerosis. The treatment of CIS patients is still debatable.