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Intravitreal recombinant tissue plasminogen activator without and with additional gas injection in patients with submacular haemorrhage associated with age‐related macular degeneration
Author(s) -
Tsymanava Anna,
Uhlig Constantin E.
Publication year - 2012
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2011.02115.x
Subject(s) - medicine , recombinant tissue plasminogen activator , macular degeneration , group b , visual acuity , group a , tissue plasminogen activator , ophthalmology , retrospective cohort study , surgery , ischemic stroke , ischemia , modified rankin scale
. Purpose: To compare intravitreal recombinant tissue plasminogen activator (rt‐PA) treatment with and without gas injection in patients with submacular haemorrhage associated with age‐related macular degeneration. Methods: We conducted a retrospective, non‐randomized comparative case study of 110 eyes from 76 women and 34 men (mean age 78.1 ± 6.9 years). Evaluations of the data were performed for baseline visit (t1), and visits 1–3 weeks (t2), 3 months (t3) and 6 months after (t4). The patients were classified according to gas treatment into group A (without gas, n = 46) and group B (with gas, n = 64) and according to rt‐PA‐dosage into group A1 and B1 (50 μg), group A2 and B2 (100 μg), and group A3 and B3 (200 μg). Results: At t4, the patients in group A had a median increase of 0.4 logMAR, and those in group B had a decrease of 0.1 logMAR (p = 0.183). The best corrected visual acuity (BCVA) remained stable or increased in 55% and 62% of patients in groups A and B, respectively (p = 0.151), in 50% and 68% of patients in groups A1 and B1, respectively (p = 0.620), in 40% and 100% of patients in groups A2 and B2, respectively (p = 0.250), and in 75% and 63% of patients in groups A3 and B3, respectively (p = 0.463). Complications were observed in 13.6% of patients. Conclusions: Best results were obtained in patients treated with 50 and 100 μg of rt‐PA and in those cases BCVA development was more beneficial if additional gas was injected.