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The optic nerve, mitochondria, age, energy, apoptosis and vision
Author(s) -
TAYLOR D
Publication year - 2010
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2010.459.x
Subject(s) - optic nerve , mitochondrion , optic neuropathy , mitochondrial dna , chronic progressive external ophthalmoplegia , leber's hereditary optic neuropathy , mfn2 , medicine , mitochondrial fusion , mitochondrial fission , biology , pathology , ophthalmology , neuroscience , microbiology and biotechnology , mitochondrial myopathy , genetics , gene
Optic Neuropathy‐ any disorder leading to dysfunction or death of retinal ganglion cells and their axons. This presentation will focus on acute and chronic post‐natal optic neuropathies due to dysfunction of cellular organelles, mitochondria in particular. A. Mitochondrial structure & function Citric Acid Cycle Oxidative phosphorylation Fusion & fission Aging DNA Mitochondrial. Why do Mitochondria need their own DNA? Nuclear Heteroplasmy B. Acute Optic Neuropathies LHON History Clinical Phases Pre‐symptomatic Acute Chronic Visual Recovery Why does the vision improve? Systemic Associations LHON‐OPA1 interaction LHON at all ages? Precipitating factors and summation Management & Treatment Present Rx Possible‐ Ooplasmic Transfer Nuclear DNA swap C. Chronic Optic Neuropathies ADOA Clinical Symptoms & signs OPA1 Functions & distribution Non‐ocular manifestations OPA1: can the vision improve? OPA 2‐OPA7 OPA3‐ ADOAplus Other chronic disorders with Optic Atrophy & organelle disease DIDMOAD Wolframin (Endo Retic) CDGSH AROA TMEM126A Leigh’s disease. ATPase subunit 6 Charcot Marie Tooth Friedreich’s ataxia Mohr Tranebjaerg Normal tension glaucoma