Premium
Changes in the retinal nerve fiber layer in patients with multiple sclerosis
Author(s) -
ASCASO FJ,
RUIZ DE GOPEGUI E,
IÑIGUEZ C,
DEL BUEY MA,
CRISTOBAL BESCOS JA
Publication year - 2010
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2010.441.x
Subject(s) - nerve fiber layer , retinal , multiple sclerosis , medicine , nerve fiber , fiber , ophthalmology , layer (electronics) , materials science , anatomy , nanotechnology , composite material , immunology
Purpose To evaluate by Optical Coherence Tomography (OCT) the presence of peripapillary retinal nerve fiber layer (RNFL) damage in patients suffering from multiple sclerosis (MS). Methods Prospective study of the peripapillary RNFL measured by Stratus OCT in 116 eyes from 58 patients divided in four groups: non optic neuritis MS patients (non ON‐MS): 35 eyes; optic neuritis MS patients (ON‐MS): 20 eyes; fellow eye optic neuritis MS patients (FE‐ON‐MS): 29 eyes; healthy controls (HC): 32 eyes. Results The peripapillary RNFL thickness is lowered not only in eyes from patients with MS and ON (81'6±20'6µm), but also in their fellow eye 92'9±13'6µm), and even in eyes from MS patients without previous history of ON (101'0±11'2µm). p< 0,05, ANOVA test. Conclusion OCT proved to be a useful device in the diagnosis of axonal damage in patients with MS.