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Role of blood markers in diagnostics of an age cataract
Author(s) -
KUDRYAVTSEVA YV,
CHUPROV AD,
TSIBEL VB,
BOJKO ER
Publication year - 2010
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2010.427.x
Subject(s) - senile cataract , medicine , lens (geology) , lipid peroxidation , selenium , aldehyde dehydrogenase , antioxidant , ophthalmology , biochemistry , physiology , chemistry , enzyme , oxidative stress , biology , paleontology , organic chemistry
Purpose To reveal in a blood some markers of changes in a lens during development of a senile cataract. Methods Objects of research were 134 patients at the age from 43 till 84 years, operated concerning a cataract. We determined degree of a cataract maturity and estimated degree of a brown shade of a lens nucleus. The molecular products of peroxidation (primary, secondary, end‐products of a lipidic and proteic genesis), enzymes of antioxidants (glutationperoxidasa, glutationreductasa, superoxide scavenger), natural antioxidants (Retinolum, tocopherol, selenium in a blood were defined. Results During the development of an age cataract the level of peroxidatoin products ‐ dienic conjugates, crotonic aldehyde and the bases of Shiffa are decreasing. Decrease of content of vitamins В2, A and Е if the intensifying of a brown shade of a lens nucleus was revealed. The content of dienic conjugates decreases, the level of crotonic aldehyde increases and the concentration of the bases of Shiffa also change. The content of selenium in a blood decreases in patients with a brown cataract but it doesn't change in patients with mature cataract. Conclusion There are markers in a blood in patients with a cataract which change at advance of opacifications and intensifying of brown colour of a lens nucleus. However its changes is non‐specific and means about the general activation of processes of peroxidation and antioxidatic system