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Correlation between basal IOP and functional damage in three different types of open angle glaucoma (OAG)
Author(s) -
CASTEJON M,
BOLIVAR G,
AREVALOSERRANO J,
ARRANZMARQUEZ E,
TEUS MA
Publication year - 2010
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2010.358.x
Subject(s) - ophthalmology , glaucoma , medicine , visual field , nerve fiber layer , basal (medicine) , insulin
Purpose To analyze the correlation between basal, untreated IOP and visual field damage in newly diagnosed Hyperbaric glaucoma (HB), Focal damage glaucoma (FG) and pseudoexfoliative glaucoma (PEXG). Methods This is a prospective, cross sectional study. Basal, untreated IOP was measured in all cases. The Retinal fiber layer (RNFL) thickness was measured using the OCT stratus 3.0 and the fast RNFL thickness strategy. Visual field was evaluated using the Humphrey field analyzer, achromatic perimetry, SITA standard 24‐2 strategy. Corneal pachimetry was measured in all eyes. Only one eye per patient was included. Linear regression analyses and Pearson’s correlation coefficients between the basal IOP and the global Visual Field (VF) indices were performed. The ANOVA test was used for comparison of the means of quantitative parameters. Results 36 HB, 43 GF and 28 PEXG eyes were included in the study. Untreated IOP was 30.9 mmHg in HB, 19.1 mmHg in FG, and 24.5 mmHg in PEXG eyes. (p=0.0001 for all comparisons). Central corneal thickness was also different in each group. PEXG eyes had the thicker corneas (568.56 microns) and FG had the thinnest corneas (527.43 microns). No significant difference was found in the RNFL thickness or in the Mean Defect of the visual field between groups. Basal IOP was significantly correlated with the VF Mean Defect in HG (p=0.006, r=0.44) and in PEXG (p=0.002, r=0.55). No statistically significant correlation was found between both parameters in FG eyes. Conclusion Different types of Open Angle Glaucomas with a similar degree of glaucomatous damage, show a different correlation between untreated IOP and visual field damage.