Premium
Vasoregulatory and neuroprotective effects of oral antioxidants against glaucomateus damage
Author(s) -
ENGIN KN,
YEMISCI B,
YIGIT U,
OZTURK R
Publication year - 2010
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2010.357.x
Subject(s) - neuroprotection , antioxidant , glaucoma , medicine , ophthalmology , pharmacology , chemistry , biochemistry
Purpose Glaucomateus damage proceeds from retinal ganglion cells to brain. Aside from their antioxidant effects, a‐tocopherol and Gingko Biloba known to be neuromediators with vasoregulatory effects on retina. In this clinical study, we aimed to evaluate vasoregulatory and neuroprotective effects of oral a‐tocopherol and Gingko Biloba beyond their antioxidant properties. Methods Equally divided 4 groups were consisted of 120 eyes of 60 patients with glaucoma. Group A recieved no antioxidant. For 3 months, groups B,C,D patients have recieved a‐tocopherol, Gingko Biloba and a strong antioxidant formula, respectively. At the begining and end of the study, all the patients were exemined with Doppler USG, Central Visual Fields, OCT and serum oxidation parameters were studied. Parametrical statystical analysis were made. Results Antioxidant intake have been confirmed with blood tests. Significant decreases in ganglion cell loss and pulsatility indexes of ophthalmic and cantral retinal arteries have been found in group C. In groups B and D, MD values and ophthalmic artery end diastolic volume were significantly higher. Conclusion Neuroprotective efect in glaucoma can be obtained with oral antioxidant intake, in short term. Gingko Biloba and a‐tocopherol merit a concern beyond other antioxidants.