Premium
Results of corneal collagen crosslinking with riboflavin and UV‐A radiation
Author(s) -
KONTADAKIS G,
KYMIONIS G,
KOUNIS G,
PORTALIOU D,
GRENTZELOS M,
LIMNOPOULOU A,
DIAKONIS V,
PALLIKARIS IG
Publication year - 2010
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2010.338.x
Subject(s) - keratoconus , corneal collagen cross linking , riboflavin , ophthalmology , stroma , cornea , medicine , confocal microscopy , chemistry , pathology , biology , immunohistochemistry , microbiology and biotechnology , biochemistry
Purpose To investigate outcomes after Corneal Collagen Cross Linking with riboflavin and UVA for the treatment of keratoconus. Methods 40 patients, 56 eyes participated in this study. Mean age was 28.9 ± 6.1 (range from 18 to 45 years). All eyes underwent Corneal Cross Linking induced by riboflavin and UV‐A. Postoperative evaluation included Uncorrected Distance Visual Acuity (UDVA), Corrected Distance Visual Acuity (CDVA), mean Keratometric values, topography and confocal microscopy analysis. Results Mean follow up was 18.35+3.12 months (range from 6 to 29 months). No intraoperative complications were observed in this series.UDVA (decimal scale) improved from 0.13±0.15 to 0.20±0.17. CDVA (decimal scale) improved from 0.45±0.24 to 0.54±0.54. No eye lost lines of CDVA. A flattening of the Mean K was observed. (From 48.84 ± 5.83D preoperatively to 47,30 ± 1,34D). Confocal microscopy analysis revealed that collagen fibres in the superior stroma after CXL were distributed unevenly similar to a net like formation. Conclusion Corneal Collagen Cross Linking induced by riboflavin and UVA is a promising new therapeutic technique for the treatment of keratoconus. Longer follow up is necessary.