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Evaluation of oxidative stress on patients with age‐related macular degeneration
Author(s) -
QUINTYN JC,
GALINIER A,
CASPARBAUBIL S,
PERIQUET B
Publication year - 2010
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2010.290.x
Subject(s) - macular degeneration , haemolysis , medicine , oxidative stress , antioxidant , vitamin e , ophthalmology , immunology , biology , biochemistry
Purpose To investigate the state of stress oxidation on age macular degeneration patients using a biological test named “KRL”. Methods This prospective study is on age macular degeneration patients with active form. No one had vitamin supplementation. The KRL testevaluates the resistance generated under standardized conditions to lyses of red blood cells treated by free radicals. We used the KRL test to evaluate the global oxidation stress on 21 patients and on 21 control patients. Results are expressed as the time that is required to reach 50% of maximal haemolysis (half‐haemolysis time, in minutes), the lower the results, the lower antioxidant capacity. Results The both groups are similar for age, sex, BMI, smoking status. The mean of red cell half time is 83,54 (SD:6.99) min for the control group and 77,81 (sd=6.29); min for the patients group. A significant haemolysis is noticed between the control group and the patients group (p<0.001). Conclusion AREDS study reported the benefit action of antioxidants against age macular degeneration. The protective mechanisms against oxidative RPE damage decrease dramatically in age macular degeneration patients. We demonstrated age macular degeneration patients have a diminution of overall antioxidant defence too. KRL test is an easy test which might use to determine the predisposed patients. The age macular degeneration patients have an increased oxidative stress. Age macular degeneration may be not only a local disease but a systemic disease too.