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Intravitreal injection of triamcinolone combined with bevacizumab for choroidal neovascularization associated with retinal pigment epithelial detachment in age‐related macular degeneration
Author(s) -
CHEBIL A,
KORT F,
BOULADI M,
BOURAOUI R,
CHAABANI L,
EL MATRI L
Publication year - 2010
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2010.256.x
Subject(s) - macular degeneration , choroidal neovascularization , medicine , ophthalmology , triamcinolone acetonide , bevacizumab , neovascularization , retinal , lesion , retinal pigment epithelium , surgery , chemotherapy , angiogenesis
Purpose To discuss the effect and outcome of a combined intravitreal triamcinolone acetonide (IVTA) injection with intravitreal bevacizumab (IVB) in treating choroidal neovascularization (CNV) associated with retinal pigment epithelial detachment (PED) in age‐related macular degeneration (AMD). Methods Ten eyes (10 patients) with CNV associated with PED in AMD were treated by IVT (4 mg/ 0.1 ml) followed by a IVB (1.25 mg/0.05 ml) one week later. Indications for retreatment by combined injection was defined as persistent DEP with subretinal and/or intraretinal fluid on OCT. Patients with flattening of the DEP and activity leakage demonstrated by OCT underwent subsequent IVT. Results The mean duration of follow up was 12 months (6 to 16 months). BCVA at baseline averaged 20/63 (range 20/200 to 20/32) and 20/58 (range 20/125 to 20/32) at the end of follow‐up. FA showed no leakage from the lesion in 6 eyes at the end of follow‐up examination and three eyes showed a decrease in leakage from that seen at baseline. Average central foveal thickness was (CFT) 366.9 microns (range 253 to 388) at baseline and 212.1 microns (range 168 to 245) at the end. the PED had disappeared in six eyes, while in the remaining four they had decreased in size at the end. The subretinal fluid had disappeared in all patients at the end. The combined treatment was repeated in 6 eyes and the number of IVB after combined injection ranged from one to three. No RPE tear appeared during follow‐up. Conclusion combined IVB and IVT therapy seems to be an effective and safe therapeutical procedure to treat CNV associated with large PED in AMD.