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Intravenous hypertonic saline reduces intraocular pressure
Author(s) -
HARJU M,
LINDBOHM N,
KOIVUSALO R,
PALOHEIMO M
Publication year - 2010
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2010.2351.x
Subject(s) - medicine , hypertonic saline , intraocular pressure , anesthesia , glaucoma , saline , ophthalmology
Purpose To study the effect of intravenous hypertonic saline (HTS) solution on intraocular pressure (IOP). Methods Nineteen patients (mean age ±SD, 66 ± 11 years) with glaucoma and IOP ≥30 mmHg were recruited. HTS solution with sodium chloride concentration of 7,5% (Natriumklorid Braun 234 mg/ml, B.Braun Medical Oy, ) was given intravenously in an antecubital vein. IOP was measured every minute for 10 minutes and less frequently for up to 2 hours after treatment. The dosage given was 0,5 mmol/kg in 11 patients (Group05) and 1,0 mmol/kg in eight patients (Group1). Results The maximum mean (±SD) IOP reduction was achieved 5 minutes after treatment at which point mean IOP had reduced from 40 ± 11 mmHg before treatment to 33 ± 12 mmHg (P < 0.001). The mean percentage IOP reduction was 20 ± 10 % (range 8% – 40%) and the absolute IOP reductions ranged 4 to 16 mmHg. Two hours after treatment, mean IOP was still reduced to 33 ± 13 mmHg (P< 0.001). There was no difference between Group05 and Group1 in the amount of IOP reduction, but there was a trend that the IOP reduction sustained longer in Group1. Four patients reported mild to severe pain in the arm after injection. Especially patients in Group1 had a feeling of warmth in the head and neck region. These symptoms lasted for 1‐2 minutes. Conclusion Intravenous HTS solution reduces IOP within minutes after injection.