Premium
Cytomegalovirus infections
Author(s) -
ATHERTON S,
ZHANG M,
MARSHALL B
Publication year - 2010
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2010.2214.x
Subject(s) - retinitis , cytomegalovirus , virology , human cytomegalovirus , retinal , retina , virus , cytomegalovirus retinitis , biology , immunology , pathogenesis , medicine , herpesviridae , viral disease , neuroscience , biochemistry
Even in the era of highly‐active retroviral therapy (HAART), some HIV‐infected patients continue to develop cytomegalovirus retinitis. The purpose of this SIS presentation is to discuss how results from a mouse model of CMV retinitis using murine CMV (MCMV) may help us understand the pathogenesis of CMV infection of the retina in immunosuppressed human patients. One interesting aspect of MCMV retinitis in the mouse that has also been described in human patients is the striking juxtaposition of uninfected retinal cells that are apoptotic with cytomegalovirus‐infected retinal cells that are not apoptotic. Using in vivo approaches (using MCMV infected BALB/c mice) as well as complementary in vitro studies (using virus infected cells), our laboratory has been attempting to decipher the virus and host cells processes that contribute to this interesting pattern of pathology. In addition to consideration of the most likely virus and cell modulators that mediate this process, the possible role of this juxtaposition of infected and uninfected retinal cells in preventing panretinal infection and/or in reducing spread of the virus in the retina during cytomegalovirus infection will be discussed.