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A comparison of the effectiveness between amniotic membrane homogenate and transplanted amniotic membrane in healing corneal damage in a rabbit model
Author(s) -
Guo Qing,
Hao Jie,
Yang Qian,
Guan Linan,
Ouyang Shan,
Wang Jianwen
Publication year - 2011
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2010.02097.x
Subject(s) - amnion , cornea , transplantation , andrology , rabbit (cipher) , membrane , ophthalmology , medicine , biology , surgery , fetus , pregnancy , biochemistry , statistics , genetics , mathematics
Abstract. Purpose: To determine whether amniotic membrane homogenate is as effective in healing corneal damage as amniotic membrane transplantation in a rabbit model. Method: The rabbits were divided into three groups. The cornea of one eye in each rabbit was incised resulting in a defect of approximately 8 mm in diameter. Amniotic membrane transplantation was performed in the first group, and amnion homogenate was administered four times a day in the second group. The third group was the control group. Results: There were no differences in the diameter of the defects and the rate of corneal growth between the amnion transplant group and the amnion homogenate group. Conclusion: Amnion homogenate is as effective as transplanted amniotic membrane in promoting corneal healing in a rabbit model.