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Retinal nerve fiber layer and macular thickness measured with Cirrus and Spectralis Fourier‐domain optical coherence tomographies: comparative study in healthy eyes.
Author(s) -
PINILLA I,
GARCIA MARTIN E,
IDOIPE M,
GIL ARRIBAS L,
FUERTES MI,
FERRERAS A
Publication year - 2009
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2009.446.x
Subject(s) - optical coherence tomography , nerve fiber layer , ophthalmology , retinal , cirrus , medicine , materials science , optometry , physics , meteorology
Purpose To compare the retinal nerve fiber layer (RNFL) measurements and macular thickness measurements in healthy eyes using two different Fourier‐domain optical coherence tomographies (OCT) devices: Cirrus HD OCT (Carl Zeiss Meditec, Dublin, Ca) and Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany). Methods Fifty healthy eyes (33 women and 17 men, aged from 23 to 59 years) were prospectively analysed using 3 optic disc protocols and 3 volume cube scans with each device. Descriptive statistics, analysis of variance and coefficients of variation (COV) were calculated for RNFL average thickness and for the 9 areas corresponding to the Early Treatment Diabetic Retinopathy Study (ETDRS) in macular protocol. Differences between the acquisitions of RNFL quadrants with both devices made them unable to compare. Results RNFL thickness measurements showed significant differences between Cirrus HD OCT and Spectralis OCT (mean: 98.91 ± 7.39 microns and 102.20 ± 7.93 microns respectively) (p<0.001). Total retinal thickness mean showed significant differences between Cirrus OCT and Spectralis OCT (mean: 269.27 ± 23.25 and 277.79 ± 20.43 microns, respectively) (p=0.032). All measurements were highly reproducible. The retinal COV were from 0.1% (nasal outer ETDRS area) to 2.3% (average thickness) using Cirrus OCT and from 0.1% (nasal outer ETDRS area) to 2.2% (inferior outer ETDRS area) with Spectralis OCT. RNFL average thickness showed lower COV using Cirrus OCT (1.36%) than Spectralis OCT (1.79%). Conclusion Fourier domain OCTs show differences between their measurements and good reproducibility to analyze RNFL and macular thickness.