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Repeatability of retinal nerve fiber layer and macular thickness measurements using Cirrus Fourier‐domain optical coherence.
Author(s) -
GARCIA MARTIN E,
PINILLA I,
IDOIPE M,
GIL ARRIBAS L,
FUERTES I,
PUEYO V
Publication year - 2009
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2009.444.x
Subject(s) - nerve fiber layer , optical coherence tomography , repeatability , intraclass correlation , retinal , ophthalmology , medicine , reproducibility , diabetic retinopathy , cirrus , optometry , mathematics , physics , diabetes mellitus , statistics , endocrinology , meteorology
Purpose To test intrasession, intersession, intervisit, and interoperator reproducibility of retinal nerve fiber layer (RNFL) measurements and retinal thickness using Cirrus Fourier‐domain optical coherence tomography (OCT). Methods Seventy‐two eyes of 72 healthy subjects underwent three macular 512x128 volume cube centered on the fovea and three 360° optic disc circular scans done by the same observer. This sequence was repeted by another observer on a second visit within a 2‐week period. Descriptive statistics, analysis of variance, intraclass correlation coefficients (ICC), and coefficients of variation (COV) were calculated for the 9 macular areas described by the Early Treatment Diabetic Retinopathy Study (ETDRS) in the macular protocol and for quadrants and RNFL clock hour sectors. Results All measurements were highly reproducible. The ICCs ranged from 0.823 to 0.992 using macular volume cube and from 0.886 to 0.984 with optic disc cube protocol. Mean differences between both operators were lower than 3 μm in all measurements and no significant differences were found. Total retinal thickness mean was 285.17 ±15.31 μm by observer 1 and 284.20 ±12.89 μm by observer 2. Mean COV was 1.2 ±0.99% (ranged from 0.5 to 1.8%) for the nine ETDRS areas. Lowest COV was found for the nasal inner area. Mean RNFL average thickness was 95.99 ±7.67 and 95.72 ±7.87 μm by observer 1 and 2, respectively. Mean COV was 4.41 ±3.01% (ranged from 1.43 to 6.66%). Conclusion Retinal and RNFL thickness measurements obtained using Cirrus Fourier‐domain OCT show good reproducibility for healthy eyes. The device is an important tool for to the diagnosis and follow‐up of retinal and optic nerve pathologies.