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The use of ruthenium plaque brachytherapy in retinoblastoma
Author(s) -
ABOUZEID H,
MOECKLI R,
GAILLARD MC,
BECKPOPOVIC M,
PICCA A,
ZOGRAFOS L,
BALMER A,
PAMPALLONA S,
MUNIER F
Publication year - 2009
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2009.4265.x
Subject(s) - brachytherapy , medicine , retinoblastoma , univariate analysis , radiation therapy , enucleation , surgery , radiology , nuclear medicine , multivariate analysis , biochemistry , chemistry , gene
Purpose To evaluate the efficacy of 106Ru plaque brachytherapy for the treatment of retinoblastoma. Methods We reviewed a retrospective, noncomparative case series of 39 children with retinoblastoma treated with 106Ru plaques at the Jules‐Gonin Eye Hospital between October 1992 and July 2006, with 12 months of follow‐up. Results A total of 63 tumors were treated with 106Ru brachytherapy in 41 eyes. The median patient age was 27 months. 106Ru brachytherapy was the first‐line treatment for 3 tumors (4.8%), second‐line treatment for 13 (20.6%), and salvage treatment for 47 tumors (74.6%) resistant to other treatment modalities. Overall tumor control was achieved in 73% at 1 year. Tumor recurrence at 12 months was observed in 2 (12.5%) of 16 tumors for which 106Ru brachytherapy was used as the first‐ or second‐line treatment and in 15 (31.9%) of 47 tumors for which 106Ru brachytherapy was used as salvage treatment. Eye retention was achieved in 76% of cases (31 of 41 eyes). Univariate and multivariate analyses revealed no statistically significant risk factors for tumor recurrence. Radiation complications included retinal detachment in 7 (17.1%), proliferative retinopathy in 1 (2.4%), and subcapsular cataract in 4 (9.7%) of 41 eyes. Conclusion 106Ru brachytherapy is an effective treatment for retinoblastoma, with few secondary complications.Local vitreous seeding can be successfully treated with 106Ru brachytherapy.