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The use of animal models for the evaluation of ocular antiviral agents
Author(s) -
ROMANOWSKI EG
Publication year - 2009
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2009.4255.x
Subject(s) - medicine , keratitis , clinical trial , antiviral treatment , antiviral therapy , animal model , dermatology , intensive care medicine , immunology , virus , pathology , chronic hepatitis
Animal models have been used extensively in the evaluation and development of topical ocular antiviral agents. Rabbit ocular models have proven predictive of the clinical efficacy of topical antiviral agents for HSV‐1 epithelial keratitis and in clinical trials for adenoviral ocular infections. The current presentation will discuss the limitations of these models and present data on potential new topical antiviral agents, focusing primarily on antivirals for adenoviral ocular infections.