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Uveal metastasis as initial manifestation of cancer
Author(s) -
NOVAK ANDREJCIC K,
KRAUT A,
TEKAVCIC POMPE M,
JANCAR B
Publication year - 2009
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2009.350.x
Subject(s) - medicine , choroid , uvea , ciliary body , metastasis , cancer , carcinoma , lung cancer , medical history , anamnesis , metastatic carcinoma , melanoma , primary tumor , radiology , oncology , ophthalmology , eye disease , retina , physics , cancer research , optics
Purpose To report clinical features of patients with uveal metastases and no known history of primary cancer at the time of ocular diagnosis. Methods A retrospective chart review of all patients with uveal metastases and with no history of primary cancer, evaluated at University Eye Hospital in Ljubljana over a 10‐year period was performed. Results A total of 9 patients, 4 women and 5 men with uveal metastases were included. Referral diagnosis was iris tumour in 2 patients, suspected uveal melanoma in 3 , choroiditis in 1 and undetermined choroidal tumour in 3 patients. None of the patients had a history of previous cancer. The diagnosis of uveal metastasis was established on the basis of medical history, clinical picture, standardised echography, fluorescein angiography and systemic evaluation. Iris and ciliary body were involved in one patient, iris in one, ciliary body and choroid in one, while choroid was the only site of metastatic involvement in 6 patients. In all patients only one eye was affected. A primary lung carcinoma was detected in 8 patients, whereas in 1 patient a primary carcinoma of the gastrointestinal tract was found. Conclusion Lung carcinoma was the most common site of primary cancer in our patients. Patients may have no known history of primary cancer at the time of ocular diagnosis, hence a thorough subsequent systemic evaluation is mandatory.