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The crystalline lens higher fatty acids influence on the lens physical characteristics
Author(s) -
KUDRYAVTSEVA Y,
CHUPROV A
Publication year - 2009
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2009.3345.x
Subject(s) - lens (geology) , polyunsaturated fatty acid , chemistry , fatty acid , oleic acid , linolenic acid , negative correlation , palmitic acid , degree of unsaturation , biochemistry , chromatography , linoleic acid , optics , medicine , physics
Purpose To study influence lipids of a crystalline lens on its physical characteristics. Methods 114 patients at the age from 55 till 78 years, with a cataract of various degree of a maturity are selected. Researches of a lens nucleus in vitro included: definition of mechanical hardness on the original device for research of mechanical hardness of a crystalline lens, research of composition of the higher fatty acids on the gas‐liquid chromatograph. Results Influence of the higher fatty acids composition on mechanical hardness of a lens nucleus is revealed. Strong direct dependence between polyunsaturated fatty acids contents and hardness of a crystalline lens is found out. The correlation factor is equal 0.7 (? <0.05). Pentadecanic and stearic acids ‐ the saturated fat acids have average correlation with hardness of lens ‐ the correlation factor is accordingly equal ‐0.6 (? <0.05) and ‐0.6 (? <0.05), in spite of low contents in the lens. The palmitic acid contains in the cataract lens in concentration comparable to level polyunsaturated fatty acids, however, essential correlation with hardness has no ‐ the correlation factor is equal 0.21 (p >0.05). The oleic, linolic and linolenic acids are contained in the cataract lens in low concentration and have average (v and linolic acids) ‐ the correlation factor is accordingly equal ‐0.5 (? <0.05) and ‐0.57 (? <0.05) and weak correlation (linolenic acid) with hardness of a crystalline lens ‐ the correlation factor is equal ‐0.22 (p> 0.05). Conclusion The polyunsaturated higher fatty acids which are a basis of membranes of a crystalline lens have the maximal influence on mechanical characteristics of the lens.