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Diffuse keratoconjunctival diseases: an in vivo confocal microscopic study
Author(s) -
DUA HS,
MIRI A,
ALOMAR T
Publication year - 2009
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2009.3234.x
Subject(s) - pathology , medicine , confocal , biopsy , in vivo , cornea , confocal microscopy , ophthalmology , biology , geometry , mathematics , microbiology and biotechnology
Purpose To establish in vivo confocal microscopic features of diffuse ocular surface disease. Methods IVCM of diffuse OSD such as chemical burns, inflammatory disease related limbal stem cell deficiency, conjunctival intraepithelial neoplasia and OS infections was carried out using the Rostock Cornea Module RCM and HRTII. In some patients subsequent biopsy or surgery allowed for histological correlation of the observed IVCM features. Results Multiple clinical and histological correlations have enabled us to establish diagnostic features of dendritic cells, inflammatory cells, metaplastic and dysplastic superficial and basal epithelial cells, goblet cells, intraepithelial cysts, corneal new vessels, subtypes of acanthamoeba cysts and other nonspecific features. These features can be seen individually or in combination in different diseases entities. Conclusion IVCM can help in making rapid clinical diagnoses without resort to biopsy or impression cytology. This in turn allows for early initiation of appropriate treatment.Commercial interest