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The effect of betablockers on ocular hemodynamics in anesthetized rabbits
Author(s) -
RUNGE CW,
BOGNER B,
STROHMAIER C,
GRABNER G,
REITSAMER HA
Publication year - 2009
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2009.268.x
Subject(s) - ciliary arteries , hemodynamics , medicine , blood flow , intraocular pressure , anesthesia , atenolol , ciliary body , heart rate , choroid , blood pressure , ophthalmic artery , cardiology , ophthalmology , retina , physics , optics
Purpose To compare the effects of different betablockers on ocular hemodynamics in anesthetized New Zealand White rabbits. Methods Mean arterial pressure (MAP), intraocular pressure (IOP) and orbital venous pressure (OVP) were measured by direct cannulation of the central ear artery, the vitreous and the orbital venous sinus, respectively. Laser Doppler flowmetry was used to measure choroidal and ciliary blood flow. The performed measurements were made continuously at baseline and after drug application. Results Metoprolol showed a significant reduction of the choroideal blood flow (‐13,6 ± 1,4%, p = < 0,05) which was not observed in the ciliary body. Atenolol had a similar effect on the choroid with a significant reduction (‐7,3 ± 1,0%, p=< 0,05) and no significant change in the ciliary body. The intravenous administration of Nebivolol produced a decrease of the choroideal blood flow (‐11,2± 0,9%, p=< 0.05) and also no significant change of the ciliary blood flow. In all three series we could detect a clear decrease of IOP and heart rate. Conclusion All tested betablockers showed vasoconstrictive effects on the choroidea. Although they are different in their nature they showed similar effects by intravenous administration on the examined parameters. A vasodilative effect of nebivolol could not be detected.