z-logo
Premium
Efficacy of bromfenac sodium ophthalmic solution in preventing cystoid macular oedema after cataract surgery in patients with diabetes
Author(s) -
Endo Naoko,
Kato Satoshi,
Haruyama Kensuke,
Shoji Munenori,
Kitano Shigehiko
Publication year - 2010
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2009.01582.x
Subject(s) - medicine , phacoemulsification , ophthalmology , cataract surgery , macular edema , diabetic retinopathy , intraocular pressure , visual acuity , intraocular lens , prospective cohort study , diabetes mellitus , surgery , endocrinology
Acta Ophthalmol. 2010: 88: 896–900 Abstract. Purpose:  To compare the efficacy of bromfenac sodium ophthalmic solution (BF) and a steroidal solution (ST) administered prophylactically against cystoid macular oedema and anterior‐chamber inflammation after phacoemulsification and intraocular lens implantation and to assess macular thickness changes using optical coherence tomography (OCT). Methods:  In this prospective study, 62 eyes of 62 patients were randomized to either the BF group ( n  = 31) or the ST group ( n  = 31). The average perifoveal thickness (AFT) was measured by OCT preoperatively, and 1 day and 1, 2, 4 and 6 weeks postoperatively. The best‐corrected visual acuity, intraocular pressure and flare in the anterior chamber were recorded at each visit. The same method was used to compare patients with non‐proliferative diabetic retinopathy (NPDR) in the BF ( n  = 16) and ST ( n  = 11) groups. Results:  In the analysis of all patients, flare in the anterior chamber was significantly (p = 0.007) lower in the BF group 2 weeks postoperatively. In patients with NPDR, the anterior chamber flare values were significantly lower in the BF group at 4 weeks (p = 0.0009) and 6 weeks (p = 0.005). The AFT values were significantly lower in the BF group at 4 weeks (p < 0.0001) and 6 weeks (p < 0.0001). No adverse events occurred in either group. Conclusion:  BF suppressed anterior chamber inflammation and increasing retinal thickening after cataract surgery in patients with NPDR.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here