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Analysis of intravitreal ranibizumab injections effects on exudative reaction complicating subfoveal choroidal neovascular age related macular degeneration (AMD)
Author(s) -
GONZALEZ CG
Publication year - 2008
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2008.6315.x
Subject(s) - medicine , ranibizumab , ophthalmology , pegaptanib , macular degeneration , visual acuity , fluorescein angiography , choroidal neovascularization , retinal , surgery , bevacizumab , chemotherapy
Abstract Purpose To evaluate the effect of RANIBIZUMAB intravitreal injections(IVT) on exudative reaction secondary to retrofoveolar neovascular AMD,at short and long term evolution Methods 110 eyes of 88 patients , 31 men,57 women, with retrofoveolar sub‐retinal neovascularisation complicating AMD .65 were inaugural cases,23 previously treated by photodynamic therapy and/ or pegaptanib IVT. Patients received intravitreal ranibizumab injection, 3 times, every 4 weeks in an inductive treatment, the next injections depending on the follow‐up results. First and 2 months’ interval follow‐up exam included ETDRS visual acuity (VA), complete ophthalmic examination, fluorescein (FA) and infracyanine (ICG) angiography, and optical coherence tomography (OCT).VA and OCT were done before each IVT.OCT was evaluated and compared time to time and cut to cut, FA and ICG analysis appreciate neovascular net’s leakage and flow. Results Exudation decreased intensely in all cases.Diffuse oedema was 70% reduced in 80% cases,cystoid oedema was 75% less in 65%, retinal serous detachment was 80% decreased in 78%.Angiographic leakage reduced about 70% in 72%.At ICG ,vascular flow wAS 2/3 time less in 55%. Best results noted than with PDT alone and/or pegaptanib IVT, and with no anastomosis lesions. Exudation scale was considered, compared with FA and ICG follow‐up results and for next IVT criteria and indications. Inductive treatment was sufficient in 74 cases. Conclusion The results, with indeed reduction of exudation on OCT, lack of fluorescein leakage, low neovascularisation’s flow in ICG, suggest Ranibizumab IVT seem effective on exudative neovascular reaction complicating AMD and OCT be the main evaluation means.