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The predictive risk factors and grading of pathologic myopia for retinal photographs
Author(s) -
SAW SM
Publication year - 2008
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2008.6253.x
Subject(s) - medicine , emmetropia , ophthalmology , macular degeneration , glaucoma , refractive error , fundus (uterus) , grading (engineering) , population , optometry , choroid , visual acuity , retina , optics , civil engineering , physics , environmental health , engineering
Purpose To determine the predictive factors and grading for pathologic myopia in several population‐based studies. Methods More than 12,000 fundus photographs are available from large population‐based studies in Singapore including the Singapore Cohort Study of the Risk Factors for Myopia (SCORM) of 1,600 children and SIMES of Malays aged 40 to 80 years. Refractive error measures were performed using the Canon RK‐F1 machine and fundus photographs using the Canon CR6‐45NM non‐mydriatic camera. The number, type and position of the following will be assessed: staphylomas, lacquer cracks, cytotorsion of optic disc, Fuch’s spots, choroidal neovascularization, lattice degeneration, and B peripapillary atrophy. In SCORM, the predictive factors including age of onset of myopia will be assessed. Additionally, genome‐wide analyses (GWA) studies using the Illumina Sentrix HumanHap 550K BeadChips were performed in 1043 SCORM samples. Results The different grades of pathologic myopia with severity of refractive error or axial length will be correlated. In 679 children in SCORM with myopia and 100 with emmetropia, the prevalence of lattice degeneration was 0.15%, there was increased PPA‐to‐disc area ratio with increased axial length and smaller cup‐to‐disc ratios in myopes compared with emmetropes. The GWA scans were run on 969 buccal‐derived and 74‐saliva derived) after excluding 82 samples. Conclusion Myopia has a huge burden because high myopia is associated with potentially visually disabling ocular pathology. Further research should identify the environmental and genetic risk factors for pathologic myopia.