Premium
Comparison between liposomes spray and non preserved tears substitutes in patients with meibomian gland dysfunction
Author(s) -
LANGMAN ME,
AMOUROUX GICQUEL N,
GICQUEL JJ
Publication year - 2008
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2008.6236.x
Subject(s) - medicine , meibomian gland , tears , ophthalmology , surgery , eyelid
Purpose Many elderly people present with lachrymal film lipid phase disorder caused by a meibomian dysfunction. During a prospective randomised study performed in Poitou‐Charente, we compared the use of vegetal liposomes in spray (intended for stabilizing the lipid phase) against one of the gold standard lachrymal substitutes. Methods 50 patients aged 75 years old or older with a functional dry eye syndrome due to a meibomian dysfunction were studied between March and June 2007 in the department of ophthalmology of St Louis Hospital. The first group was treated with vegetal liposomes spray (Vyséo®) (3 sprays /day, eyelids closed). The control group received lachrymal substitutes (Refresh Tears® (Polyvynilic alcohol and Polyvidone) 1 eyedrop 6 tid). The following criteria have been studied: inflammation of the eyelids edge, lid‐parallel conjunctival folds (LIPCOF), break up time (BUT), Schirmer I, best corrected visual acuity (BCVA) and Root Mean Square (RMS) with the Imagine Eyes IRX3 wavefront aberrometer. The statistical analysis was done with Prism for Windows. Results The improvement of inflammation at the eyelids edge, LIPCOF, BUT, and RMS was significantly higher in the group treated by Vyséo®. The Schirmer I had not been modified in neither of the two groups. The best patients’ satisfaction and ease of use scores were found in the Vyséo® group. Conclusion Vegetal liposomes spray is easy to use for elderly patients with meibomian dysfunction and provide them with effective long term discomfort relief.