Electrogenesis of the retina in proceeding glaucomatous optical neuropathy

Purpose to investigate some branches of the pathogenetic mechanisms of eye function’s disturbance in patients with the glaucomatous optic neuropathy(GON) with normalized intraocular pressure(IOP) Methods 12 p‐s(23 eyes) with primary open angle glaucoma(POAG) of I‐IIIa study and normalized IOP by conservative treatment or after operation and 7 healthy volunteers were investigated. Standard (ISCEV) methods of record of the electroretinogram (ERG)and the original method of the oscillatory potentials (OPs) recording in light adaptation were used. Oscillations O1,O2 and O3 of the flicker 30Hz ERG were filtered on frequencies of 80 and 120Hz(MBN’s equipment). Heidelberg retinal tomography(HRT), central field perimetry(CFP) on 30(Humphry) also were used Results The correlation between decreasing of O3 and increasing of excavation of the optic nerve disc by HRT‐data was obtained. Attenuation of amplitude of cones’ oscillations O1 and O2 was linked with magnification of the degree of CFP’s declension from the age norm (PSD). Decreasing of O1‐oscillation amplitude was linked with the increasing of average elevation of CFP threshold mean(MD) Conclusion 1.The genesis of the O1, O2 and O3 in flicker 30Hz ERG is differ in comparing with the genesis of OPs registered in dark adaptation, and is linked with the light on and dark off‐channels of the cone retinal system. 2.Appearing indices of the retinal ischemia O1, O2 and O3, picked out from the flicker 30Hz ERG, show the link with the functional state of the retinal neurons in the light on‐ and dark off‐channels of midget pathway. The O3‐oscillation displays the neuronal links disturbance of the ganglion cells that is proving the degree of apoptosis’ evolution