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Factors influencing the outcome of the treatment of allograft corneal graft rejection
Author(s) -
PERERA CM,
JHANJI V,
BELTZ J,
LAMOUREUX E,
POLLOCK G,
VAJPAYEE RB
Publication year - 2008
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2008.5434.x
Subject(s) - medicine , keratoconus , corneal neovascularization , corneal graft , graft rejection , corneal transplantation , ophthalmology , corneal transplant , surgery , neovascularization , edema , retrospective cohort study , cornea , transplantation , angiogenesis
Purpose To identify clinical characteristics of patients which influence the outcome of treatment of allograft corneal graft rejection. Methods A retrospective chart review of 197 cases of corneal graft rejections was undertaken at the Royal Victorian Eye and Ear Hospital, Melbourne over a period of ten years from 1997‐2007. Cases were divided into two groups according to the response to the treatment after allograft corneal rejection. Main parameters evaluated were demographic characteristics, primary indication of corneal graft and preoperative donor characteristics. Results Corneal graft rejection was successfully treated in 163 cases and 34 cases failed to respond to therapy. Both the groups were age (p=0.12) and sex‐matched (p=0.85). Keratoconus was more common as the primary indication for corneal graft in the group that had good response to the treatment (19% vs 5.9%; p= 0.08). Cases that failed to respond to treatment had higher number of recipient grafts > 9mm (9.4% vs 1.3%; p=0.04). Preoperative corneal neovascularization (adjusted odds ratio aOR= 4.8, p=0.03), and corneal edema at presentation of rejection episode (aOR=5.2, p=0.01) were associated with treatment failure. Conclusion Preoperative corneal neovascularization and corneal edema were found to be associated with failure of treatment in cases with allograft corneal graft rejection.