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Enhanced levels of VEGF and reduced levels of VEGFxxxb in the vitreous of patients with retinal vein occlusion
Author(s) -
MICHELS D,
RENNEL ES,
FELTGEN N,
MARTIN G,
STAHL A,
HANSEN LL,
AGOSTINI HT
Publication year - 2008
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2008.4417.x
Subject(s) - central retinal vein occlusion , medicine , branch retinal vein occlusion , ophthalmology , vitrectomy , retinopathy , diabetic retinopathy , macular edema , retinal , diabetes mellitus , visual acuity , endocrinology
Purpose To investigate the role of VEGF and VEGFxxxb in the pathogenesis of Central Retinal Vein Occlusion (CRVO) and Branch Retinal Vein Occlusion (BRVO). Methods In a cross sectional study we analyzed the vitreous of patients with CRVO (ischemic and non‐ischemic) and BRVO. A group of patients with vitrectomy not due to CRVO/BRVO served as control. The vitreous of 25 patients with CRVO, of 28 patients with BRVO and of 32 patients with no sign of CRVO/BRVO were analyzed using ELISA for VEGF and VEGFxxxb. Results The ratio CRVO/controls for VEGF was 5.5, and 2.5 in BRVO/controls. In comparison the VEGFxxxb ratio in CRVO/controls was 0.19, and 0.85 in BRVO/controls. Conclusion Total VEGF levels in patients with CRVO and BRVO are significantly upregulated compared to controls. The finding of a significantly down‐regulated antiangiogenic VEGFxxxb in patients with CRVO is similar to the altered balance of the splice variants found in vitreous samples of patients with proliferative diabetic retinopathy.